Details

Autor(en) / Beteiligte

• Burns, David N.
• FitzGerald, Gordon
• Semba, Richard
• Hershow, Ronald
• Zorrilla, Carmen
• Pitt, Jane
• Hammill, Hunter
• Cooper, Ellen R.
• Fowler, Mary Glenn
• Landesman, Sheldon

Titel

Vitamin A Deficiency and Other Nutritional Indices During Pregnancy in Human Immunodeficiency Virus Infection: Prevalence, Clinical Correlates, and Outcome

Ist Teil von

• Clinical infectious diseases, 1999-08, Vol.29 (2), p.328-334

Ort / Verlag

Chicago, IL: The University of Chicago Press

Erscheinungsjahr

1999

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Vitamin A levels in plasma and other nutritional indices were measured during pregnancy for 449 women enrolled in a multicenter cohort study of mother-to-infant transmission of human immuno-deficiency virus type 1 (HIV-1). During the third trimester, 29.6% of the women had low (20 to <30 μg/dL) and 11.1% had very low (<20 μg/dL) vitamin A levels. Vitamin A and body mass index, serum albumin levels, and hemoglobin levels were weakly correlated. After adjustment for other covariates, women with low and very low vitamin A levels before the third trimester were more likely to deliver infants with low birth weight (<2500 g) than were those with higher levels (odds ratio [OR], 4.58; 95% confidence interval [CI], 1.57–13.4; and OR, 6.99; 95% CI, 1.09–45.0, respectively). However, there was no statistically significant association between vitamin A level and mother-toinfant transmission of HIV-1. Anemia and low body mass index before the third trimester were associated with an increased risk of transmission in univariate analyses but not in multivariate analyses.