Details

Autor(en) / Beteiligte

• Chmielewski, Jeremy
• Haun, Michelle
• Topmiller, Krista
• Ward, Jacob
• Church, Kevin M.

Titel

AMINO-THIOCYANATION OF ELECTRON RICH OLEFINS AS AN EFFICIENT PURINE AND PYRIMIDINE N-ALKYLATION PROCESS

Ist Teil von

• Synthetic communications, 2002-01, Vol.32 (3), p.343-353

Ort / Verlag

Taylor & Francis Group

Erscheinungsjahr

2002

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• This work describes a relatively simple process to form thiocyanate substituted nucleoside mimics. ClSCN is slowly added to a solution of silylated heterocycle and suitable electron rich alkene. N-alkylated heterocycles are isolated in good yields after hydrolytic workup and flash chromatography.