Details

Autor(en) / Beteiligte

• Dissmore, Tixieanna
• DeMarco, Andrew G
• Jayatilake, Meth
• Girgis, Michael
• Bansal, Shivani
• Li, Yaoxiang
• Mehta, Khyati
• Sridharan, Vijayalakshmi
• Gill, Kirandeep
• Bansal, Sunil
• Tyburski, John B
• Cheema, Amrita K

Titel

Longitudinal metabolic alterations in plasma of rats exposed to low doses of high linear energy transfer radiation

Ist Teil von

• Journal of environmental science and health. Part C: Toxicology and carcinogenesis, 2021-04, Vol.39 (2), p.219-233

Ort / Verlag

United States: Taylor & Francis

Erscheinungsjahr

2021

Quelle

Taylor & Francis

Beschreibungen/Notizen

• Astronauts embarking on deep space missions are at high risk of long-term exposure to low doses of high linear energy transfer (LET) radiation, which can contribute to the development of cancer and multiple degenerative diseases. However, long term effects of exposure to low doses of high LET radiation in plasma metabolite profiles have not been elucidated. We utilized an untargeted metabolomics and lipidomics approach to analyze plasma obtained from adult male Long Evans rats to determine the longitudinal effects of low-dose proton and low-dose oxygen ion whole-body irradiation on metabolic pathways. Our findings reveal that radiation exposure induced modest changes in the metabolic profiles in plasma, 7 months after exposure. Furthermore, we identified some common metabolite dysregulations between protons and oxygen ions, which may indicate a similar mechanism of action for both radiation types.