Details

Autor(en) / Beteiligte

• Hoepler, Wolfgang Paul
• Weidner, Lisa
• Traugott, Marianna Theresia
• Neuhold, Stephanie
• Meyer, Elias Laurin
• Zoufaly, Alexander
• Seitz, Tamara
• Kitzberger, Reinhard
• Baumgartner, Sebastian
• Pawelka, Erich
• Karolyi, Mario
• Grieb, Alexander
• Hind, Julian
• Laferl, Hermann
• Friese, Emanuela
• Wenisch, Christoph
• Aberle, Stephan Walter
• Aberle, Judith Helene
• Weseslindtner, Lukas
• Jungbauer, Christoph

Titel

Adjunctive treatment with high-titre convalescent plasma in severely and critically ill COVID-19 patients - a safe but futile intervention. A comparative cohort study

Ist Teil von

• Infectious diseases (London, England), 2021-11, Vol.53 (11), p.820-829

Ort / Verlag

Taylor & Francis

Erscheinungsjahr

2021

Beschreibungen/Notizen

• Convalescent plasma (CP) containing antibodies derived from coronavirus disease 2019 (COVID-19) survivors has been proposed as a promising therapeutic option for severe COVID-19. In our intensive care unit (ICU), 55 patients (46 male, median age 61 years) with PCR-confirmed COVID-19 (35 = 63.6% on mechanical ventilation, 7 = 14.5% on high-flow nasal oxygen, 12 = 20% on non-invasive ventilation, 1 = 1.8% without respiratory support) were treated with high-titre CP (200 mL per dose, range 1-6 doses, median 3 doses per patient, minimum titre > 1:100, Wantai test). 139 COVID-19 patients treated in the same ICU who did not receive CP served as control group. In 27 patients, the effect of CP on the individual levels of SARS-CoV-2 IgG antibodies was assessed by ELISA in serum sample pairs collected before and after CP transfusion. The first CP dose was administered at a median of 8 days after symptom onset. 13 patients in the plasma cohort died (28-day mortality 24.1%), compared to 42 (30.2%) in the cohort who did not receive CP (p = 0.5, Pearson Chi-squared test). Out of the 27 individuals investigated for the presence of IgG antibodies, 8 did not have detectable IgG levels before the first CP transfusion. In this subpopulation, 3 patients (37.5%) died. Not a single confirmed adverse reaction to CP was noted. While adjunctive treatment with CP for severe and life-threatening COVID-19 was a very safe intervention, we did not observe any effect on mortality.