Details

Autor(en) / Beteiligte

• Ji, Ningfei
• Zhang, Mingshun
• Ren, Liang
• Wang, Yunyun
• Hu, Bicheng
• Xiang, Jie
• Gong, Yingyun
• Wu, Chaojie
• Qu, Guoqiang
• Ding, Wenqiu
• Yin, Zhiqiang
• Li, Shan
• Wang, Zhengxia
• Zhou, Lianzheng
• Chen, Xueqin
• Ma, Yuan
• Tang, Jinhai
• Liu, Yun
• Liu, Liang
• Huang, Mao

Titel

SARS-CoV-2 in the pancreas and the impaired islet function in COVID-19 patients: SARS-CoV-2 infection impairs islet function

Ist Teil von

• Emerging microbes & infections, 2022-12, Vol.11 (1), p.1115-1125

Ort / Verlag

Taylor & Francis

Erscheinungsjahr

2022

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• Diabetes mellitus (DM) is one of the most common underlying diseases that may aggravates COVID-19. In the present study, we explored islet function, the presence of SARS-CoV-2 and pathological changes in the pancreas of patients with COVID-19. Oral glucose tolerance tests (OGTTs) and the C-peptide release test demonstrated a decrease in glucose-stimulated C-peptide secretory capacity and an increase in HbA1c levels in patients with COVID-19. The prediabetic conditions appeared to be more significant in the severe group than in the moderate group. SARS-CoV-2 receptors (ACE2, CD147, TMPRSS2 and neuropilin-1) were expressed in pancreatic tissue. In addition to SARS-CoV-2 virus spike protein and virus RNA, coronavirus-like particles were present in the autophagolysosomes of pancreatic acinar cells of a patient with COVID-19. Furthermore, the expression and distribution of various proteins in pancreatic islets of patients with COVID-19 were altered. These data suggest that SARS-CoV-2 in the pancreas may directly or indirectly impair islet function.