Details

Autor(en) / Beteiligte

• Xiao, Yong
• Wu, Dongwen
• Shi, Xiao
• Liu, Shuzhong
• Hu, Xudong
• Zhou, Chenliang
• Tian, Xia
• Liu, Huimin
• Long, Hui
• Li, Zhihong
• Wang, Ji
• Tan, Tao
• Xu, Ying
• Chen, Bitao
• Liu, Ting
• Zhang, Heng
• Zheng, Shihua
• Hu, Shunlin
• Song, Jun
• Tang, Jie
• Song, Jichun
• Cheng, Zhengwei
• Xu, Weitian
• Shen, Yongxiang
• Yu, Wenhu
• Xu, Yong
• Li, Jiao
• Zhou, Jing
• Wang, Fen
• Chen, Mingkai

Titel

High Child-Pugh and CRUB65 scores predict mortality of decompensated cirrhosis patients with COVID-19: A 23-center, retrospective study

Ist Teil von

• Virulence, 2021-12, Vol.12 (1), p.1199-1208

Ort / Verlag

United States: Taylor & Francis

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Taylor & Francis Journals Auto-Holdings Collection

Beschreibungen/Notizen

• Background: COVID-19 has rapidly become a major health emergency worldwide. The characteristic, outcome, and risk factor of COVID-19 in patients with decompensated cirrhosis remain unclear. Methods: Medical records were collected from 23 Chinese hospitals. Patients with decompensated cirrhosis and age- and sex-matched non-liver disease patients were enrolled with 1:4 ratio using stratified sampling. Results: There were more comorbidities with higher Chalson Complication Index (p < 0.001), higher proportion of patients having gastrointestinal bleeding, jaundice, ascites, and diarrhea among those patients (p < 0.05) and in decompensated cirrhosis patients. Mortality (p < 0.05) and the proportion of severe ill (p < 0.001) were significantly high among those patients. Patients in severe ill subgroup had higher mortality (p < 0.001), MELD, and CRUB65 score but lower lymphocytes count. Besides, this subgroup had larger proportion of patients with abnormal (PT), activated partial thromboplatin time (APTT), D-Dimer, alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBL) and Creatinine (Cr) (p < 0.05). Multivariate logistic regression for severity shown that MELD and CRUB65 score reached significance. Higher Child-Pugh and CRUB65 scores were found among non-survival cases and multivariate logistic regression further inferred risk factors for adverse outcome. Receiver Operating Characteristic (ROC) curves also provided remarkable demonstrations for the predictive ability of Child-Pugh and CRUB65 scores. Conclusions: COVID-19 patients with cirrhosis had larger proportion of more severely disease and higher mortality. MELD and CRUB65 score at hospital admission may predict COVID-19 severity while Child-Pugh and CRUB65 score were highly associated with non-survival among those patients.