Details

Autor(en) / Beteiligte

• Mousa, Ayman M.
• Alhumaydhi, Fahad A.
• Abdellatif, Ahmed A. H.
• Abdulmonem, Waleed Al
• AlKhowailed, Mohammad S.
• Alsagaby, Suliman A.
• Al Rugaie, Osamah
• Alnuqaydan, Abdullah M.
• Aljohani, Abdullah S. M.
• Aljasir, Mohammad
• Alwashmi, Ameen S. S.
• Soliman, Khaled E. A.
• Yosof, Mohamad Y. R.
• Elsheikh, Sayed Y.
• Babiker, Ali Yousif
• Alsuhaibani, Sultan A.
• Hegazy, Ahmed M. S.
• Seleem, Hanan S.

Titel

Curcumin and ustekinumab cotherapy alleviates induced psoriasis in rats through their antioxidant, anti-inflammatory, and antiproliferative effects

Ist Teil von

• Cutaneous and ocular toxicology, 2022-01, Vol.41 (1), p.33-42

Ort / Verlag

England: Taylor & Francis

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• Psoriasis is a chronic multifactorial inflammatory disease that affects 3% of people worldwide. Ustekinumab is a selective anti-IL-12/23 biologic that alleviates psoriasis, and curcumin is a natural, effective dietary turmeric extract applied to treat numerous diseases through its antioxidant and anti-inflammatory effects. The current study evaluated the therapeutic effects of curcumin and ustekinumab cotherapy (CUC) on imiquimod (IQ)-induced psoriasis in a rat model. Twenty rats were divided into four groups, G1 (control group), G2 (IQ-treated group), G3 (IQ + ustekinumab), and G4 (IQ + CUC). Clinical, histopathological (HP), immunohistochemical (IHC), antioxidant, and biochemical investigations evaluated the efficacy of these drugs for treating IQ induced-psoriasis. Rats of G2 exhibited clinical signs of psoriatic skin lesions (erythema, scaling, and skin thickening) with epidermal changes (acanthosis and parakeratosis). Additionally, the biochemical analysis revealed significant (p < 0.05) reductions in the levels of antioxidant biomarkers (SOD, GPx, and CAT) with significant (p < 0.05) elevations in psoriasis-related cytokines (TNF-α, IL-17A, IL-12P40, and IL-23). In contrast, CUC alleviated the psoriatic changes in G4 better than ustekinumab monotherapy in G3. Ustekinumab inhibits the inflammatory cytokines IL-12P40 and IL-23, while curcumin has antioxidant effects (increasing SOD, GPx, and CAT levels) with anti-inflammatory effects (decreasing the proinflammatory cytokine TNF-α and IL-17). Therefore, CUC could be an excellent cost-effective regimen that can improve the treatment of psoriasis by the synergistic effects of CUC. Highlights IQ-induces psoriasis by elevating TNF-α, IL-17A, IL-12, and IL-23 and decreasing GPx, SOD, and CAT Ustekinumab exhibits anti-inflammatory effects by inhibiting IL-12 and IL-23 Curcumin inhibits TNF-α and IL-17A, and increases GPx, SOD, and CAT levels CUC mitigates psoriasis by synergistic antioxidant and anti-inflammatory effects CUC inhibits TNF-α, IL-17A, IL-12, and IL-23 and increases GPx, SOD, and CAT levels