Details

Autor(en) / Beteiligte

• Maruyama, Tokumi
• Utzumi, Kunihiko
• Sato, Yoshiko
• Richman, Douglas D.

Titel

Synthesis and Anti-HIV Activity of 6-Substituted Purine 2′-Deoxy-2′-fluororibosides

Ist Teil von

• Nucleosides & nucleotides, 1994-03, Vol.13 (1-3), p.527-537

Ort / Verlag

Monticello, NY: Taylor & Francis Group

Erscheinungsjahr

1994

Quelle

Taylor & Francis

Beschreibungen/Notizen

• 3′,5′-Di-O-protected 6-chloropurine arabinoside 4b was treated with diethylaminosulfur trifluoride (DAST) and subsequently deprotected with pyridinium p-toluenesulfonate to give 6-chloropurine 2′-deoxy-2′-fluororiboside 6a. The displacement with nucleophile afforded the 6-substituted congener 6b-e. Treatment of 5′-O-protected 6-chloropurine arabinoside 3c with DAST gave lyxoepoxide 7.