Details

Autor(en) / Beteiligte

• Abdel-Ghaffar, Amany
• Elhossary, Ghada G.
• Mahmoud, Atef M.
• Elshazly, Amany H. M.
• Hassanin, Olfat A.
• Saleh, Anisa
• Mansour, Sahar M.
• Metwally, Fatma G.
• Hanafy, Laila K.
• Karam, Sawsan H.
• Darweesh, Neveen
• Ata, Ahmed Mostafa

Titel

Effects of 4-phenylbutyric acid on the development of diabetic retinopathy in diabetic rats: regulation of endoplasmic reticulum stress-oxidative activation

Ist Teil von

• Archives of physiology and biochemistry, 2023-07, Vol.129 (4), p.964-974

Ort / Verlag

England: Taylor & Francis

Erscheinungsjahr

2023

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• There are good evidences suggesting that endoplasmic reticulum (ER) stress can be one of the contributing factors in the development of diabetic retinopathy. The present study was designed to investigate the effect of chemical chaperone 4-phenylbutyric acid (4-PBA) in alleviating the ER stress, and diabetic retinopathy in type 2 diabetic rats. Treatment of diabetic rats with 4-PBA, increased the antioxidant capacity, reduced the levels of lipid peroxidation, organised the state of apoptosis and regulated the ER stress - oxidative activation in retinal tissue. Also there was an improvement in the histological picture of retinal specimens compared to untreated diabetic rats. It was concluded that 4-PBA is a promising therapeutic agent for ER stress diseases such as diabetic retinopathy.