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Nickel exposure and plasma levels of biomarkers for assessing oxidative stress in nickel electroplating workers
Ist Teil von
Biomarkers, 2017-07, Vol.22 (5), p.455-460
Ort / Verlag
England: Taylor & Francis
Erscheinungsjahr
2017
Link zum Volltext
Quelle
Taylor & Francis Journals Auto-Holdings Collection
Beschreibungen/Notizen
Context: The mechanism of nickel-induced pathogenesis remains elusive.
Objective: To examine effects of nickel exposure on plasma oxidative and anti-oxidative biomarkers.
Materials and methods: Biomarker data were collected from 154 workers with various levels of nickel exposure and from 73 controls. Correlations between nickel exposure and oxidative and anti-oxidative biomarkers were determined using linear regression models.
Results: Workers with a exposure to high nickel levels had significantly lower levels of anti-oxidants (glutathione and catalase) than those with a lower exposure to nickel; however, only glutathione showed an independent association after multivariable adjustment.
Discussion and conclusion: Exposure to high levels of nickel may reduce serum anti-oxidative capacity.