Details

Autor(en) / Beteiligte

• Clifford, Maggie
• Bannon, Sarah
• Bednar, Erica M.
• Czerwinski, Jennifer
• Davis, Jessica
• Dunnington, Leslie
• Shahrukh Hashmi, S.
• DiNardo, Courtney D.

Titel

Clinical applicability of proposed algorithm for identifying individuals at risk for hereditary hematologic malignancies

Ist Teil von

• Leukemia & lymphoma, 2019-10, Vol.60 (12), p.3020-3027

Ort / Verlag

United States: Taylor & Francis

Erscheinungsjahr

2019

Beschreibungen/Notizen

• Multiple genes have been identified to cause hereditary predispositions to hematologic malignancies, and characterized by an increased risk to develop myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), and/or aplastic anemia (AA). Referral algorithms for patients who may be at higher risk have been proposed, with limited data regarding applicability. Our study aimed to evaluate referral criteria on a population of MDS/AML/AA patients. Demographic information and medical history were obtained from 608 patients referred over a 9-month period. Median age at diagnosis was 67 years (56-73), 387 (64%) were male, and the majority of individuals (54.9%) had AML. Overall, 406 individuals (66.8%) had insufficient documentation to determine whether certain criteria were met. Two hundred and two (33.2%) individuals met at least one criteria for genetic counseling referral; however, only nine (4.5%) were referred. Increased documentation of personal and family history is necessary to better assess and validate the applicability of these criteria.