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Regulation of the intestinal tight junction by natural polyphenols: A mechanistic perspective
Ist Teil von
Critical reviews in food science and nutrition, 2017-12, Vol.57 (18), p.3830-3839
Ort / Verlag
United States: Taylor & Francis
Erscheinungsjahr
2017
Link zum Volltext
Quelle
Taylor & Francis
Beschreibungen/Notizen
Impairment of the epithelial barrier function is closely linked to the pathogenesis of various gastrointestinal diseases, food allergies, type I diabetes, and other systematic diseases. Plant-derived polyphenols are natural secondary metabolites and exert various physiological benefits, including anti-inflammatory, anti-oxidative, anti-carcinogenic, and anti-aging effects. Recent studies also show the role of plant polyphenols in regulation of the intestinal barrier and prevention of intestinal inflammatory diseases. Here we summarize the regulatory pathways and mediators linking polyphenols to their beneficial effects on tight junction and gut epithelial barrier functions, and provide useful information about using polyphenols as nutraceuticals for intestinal diseases.