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Degree of lipid saturation affects depressive-like behaviour and gut microbiota in mice
Ist Teil von
International journal of food sciences and nutrition, 2020-05, Vol.71 (4), p.440-452
Ort / Verlag
England: Taylor & Francis
Erscheinungsjahr
2020
Link zum Volltext
Quelle
Taylor & Francis
Beschreibungen/Notizen
This study explored the effects of the degree of lipid saturation on depressive behaviour and gut microbiota in mice. Thirty-two mice were divided into normal (N), Prozac (NP), lard (L) and fish oil (F) groups. After a 12-week dietary intervention, the open field test (OFT) and the forced swim test (FST) were conducted before sacrifice. The mice in the L group exhibited anxiety-like behaviours in the OFT and depressive-like behaviours in the FST. A significant difference was observed in β-diversity indices between the L group and the F group. The abundance of Allobaculum and Bifidobacterium was significantly higher in the F group than in the L and N groups. The prefrontal cortex fatty acid composition was altered in various lipid-treated groups and was highly correlated with depressive-like behaviours. In conclusion, the degree of lipid saturation affects depressive-like behaviour, gut microbiota composition, and the prefrontal cortex fatty acid profile in mice.