Details

Autor(en) / Beteiligte

• Jia, Sheng-Nan
• Wen, Fu-Xing
• Gong, Ting-Ting
• Li, Xin
• Wang, Hui-Jie
• Sun, Ya-Min
• Yang, Ze-Cheng

Titel

A review on the efficacy and safety of iodine-125 seed implantation in unresectable pancreatic cancers

Ist Teil von

• International journal of radiation biology, 2020-03, Vol.96 (3), p.383-389

Ort / Verlag

England: Taylor & Francis

Erscheinungsjahr

2020

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Background: Pancreatic cancers are the common digestive system tumors with poor prognosis and due to its late diagnosis, surgical resection does not remain a viable treatment option in about 80% of patients. Amongst different treatment options, radioactive 125 I seed implantation therapy has also emerged as a good alternative in non-resectable pancreatic cancer patients. Purpose: The present review describes the efficacy and safety of iodine-125 seed implantation in unresectable pancreatic cancers in preclinical and clinical studies. Results: In this technique, small radioactive particles are implanted inside the tumor cells to produce the sustain effects. Due to the short radial distance of these radiations, there is a selective and efficient killing of cancer cells without any significant injury to the neighboring cells. Amongst the different methods for implanting 125 I seeds in the pancreatic tissues, CT scan or ultrasound-guided percutaneous seed implantation is preferred as it offers shorter operative time, lesser bleeding, early recovery, lesser complications, and low medical costs. The clinical studies have shown that radioactive 125 I seed implantation is a good option for the management of local tumor growth, pain palliation, and improvement in the life span of patients suffering from unresectable pancreatic cancer. Conclusion: It may be employed either alone or in combination with cryotherapy, existing chemotherapy, bypass surgery or radiations to achieve the optimal results in these patients. Nevertheless, there is a need to formulate a uniform dose and procedure to achieve homogeneity and develop references for clinical practices.