Details

Autor(en) / Beteiligte

• Sekitoh, Takanari
• Okamoto, Takashi
• Fujioka, Akiho
• Tramis, Olivier
• Takeda, Koji
• Matsuura, Tsutashi
• Imanaka, Hiroyuki
• Ishida, Naoyuki
• Imamura, Koreyoshi

Titel

Sole-amorphous-sugar-based solid dispersion of curcumin and the influence of formulation composition and heat treatment on the dissolution of curcumin

Ist Teil von

• Drying technology, 2021-09, Vol.39 (14), p.2065-2074

Ort / Verlag

Philadelphia: Taylor & Francis

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Taylor & Francis

Beschreibungen/Notizen

• An amorphous solid dispersion technique, in which hydrophobic drug molecules are dispersed in an amorphous matrix comprised solely of a sugar, was applied to curcumin that has excellent physiological functions. The sole-amorphous-sugar-based solid dispersion (SAS-SD) of curcumin was prepared by vacuum foam drying from methanol, using various disaccharides as the drug carrier-forming component. Aqueous dissolution of curcumin from the SAS-SD showed "spring-and-parachute" shape profile and was markedly increased when a sugar (α-maltose or trehalose) was added in a composition range ≥100 g-sugar/g-curcumin. Further dissolution was achieved by heating the SAS-SD at close to and above the melting points of curcumin.