Details

Autor(en) / Beteiligte

• Bielawska, Halszka
• Michalska, Maria

Titel

2-Deoxyglycosyl Phosphorodithioates. A Novel Type of Glycosyl Donor. Efficient Synthesis of 2'-Deoxydisaccharides

Ist Teil von

• Journal of carbohydrate chemistry, 1991-01, Vol.10 (1), p.107-112

Ort / Verlag

Monticello, NY: Taylor & Francis Group

Erscheinungsjahr

1991

Quelle

Taylor & Francis Online

Beschreibungen/Notizen

• The occurrence of 2'-deoxydisaccharides as structural units of a number of biologically important natural products explains the efforts involved in their synthesis. 1 The majority of the reported procedures is based on addition reactions to glycals leading to 2-deoxyglycosyl donors which can be directly condensed with sugar aglycones yielding 2'-deoxydisaccharides or to glycosylating reagents with a "cryptodeoxy" function, which is removed under mild conditions after the formation of the glycosidic linkage. The main disadvantage of 2-deoxyglycosyl donors such as 2-deoxyglycosyl halides, is their chemical and configurational instability.