Details

Autor(en) / Beteiligte

• Guilherme, João Paulo L. F.
• V. Shikhova, Yulia
• R. Dondukovskaya, Rimma
• A. Topanova, Alexandra
• A. Semenova, Ekaterina
• V. Astratenkova, Irina
• Ahmetov, Ildus I.

Titel

Androgen receptor gene microsatellite polymorphism is associated with muscle mass and strength in bodybuilders and power athlete status

Ist Teil von

• Annals of human biology, 2021-02, Vol.48 (2), p.142-149

Ort / Verlag

England: Taylor & Francis

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Taylor & Francis Journals Auto-Holdings Collection

Beschreibungen/Notizen

• The androgen receptor (AR) gene contains a polymorphic trinucleotide (CAG) microsatellite repeat sequence (short or long alleles) that has been associated with fat-free mass in untrained men, which needs to be replicated in athletic cohorts. The purpose of this study was to explore the AR (CAG) n polymorphism in trained individuals. A total of 61 professional bodybuilders (40 males, 21 females), 73 elite male sprinters and weightlifters and 186 male controls were enrolled in this study. The influence of the AR (CAG) n polymorphism on muscle mass and strength was assessed in bodybuilders, while the frequencies of AR (CAG) n alleles were compared between power athletes and non-athletes. The polymorphism was associated with anthropometric and strength measurements in bodybuilders of both genders. Those with ≥21 CAG repeats (i.e. carriers of long alleles) exhibited greater (p < 0.05) body mass index, absolute muscle mass, arm/thigh circumference and upper/lower limb strength compared to those with <21 CAG repeats. Furthermore, carriers of ≥21 CAG repeats were more frequent among power athletes compared to controls (p = 0.0076). Long alleles of the AR (CAG) n polymorphism were associated with greater muscle mass and strength in bodybuilders, and power athlete status.