Details

Autor(en) / Beteiligte

• Xu, Yiting
• Ma, Xiaojing
• Shen, Yun
• Xiong, Qin
• Zhang, Xueli
• Bao, Yuqian

Titel

Serum osteocalcin level as an indicator of low-grade albuminuria in Chinese men free of kidney disease

Ist Teil von

• Current medical research and opinion, 2019-04, Vol.35 (4), p.667-673

Ort / Verlag

England: Taylor & Francis

Erscheinungsjahr

2019

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Objective: The presence of low-grade albuminuria (LGA) suggested that the pathophysiology of vascular dysfunction has been initiated. Clear evidence supports a role for osteocalcin in energy metabolism and a great incidence of pathological cardiovascular changes. The observational community-based study aims to examine the association of osteocalcin with LGA, which may provide new insight into potential involvement of osteocalcin in cardiovascular diseases. Methods: A total of 1951 adults [58.37 (53.34-63.13) years, 41.3% men] from Shanghai were enrolled. LGA was defined as a urinary albumin-to-creatinine ratio (UACR) < 30 mg/g. Serum osteocalcin was measured using an electrochemiluminescence immunoassay. Results: Serum osteocalcin level in men decreased with increasing UACR after adjusting for potential covariates (p = 0.045); however, the adjusted association disappeared in women (p = 0.258). Linear regression analysis showed that osteocalcin was a negative variable of UACR in men (standardized β = −0.074, p = 0.030), particularly prominent in non-hyperglycemic, non-hypertensive men, even regardless of estimated glomerular filtration rate (eGFR) (60 ≤ eGFR <90 mL/min/1.73 m 2 , standardized β =−0.422, p = 0.004; ≥ 90 mL/min/1.73 m 2 , standardized β = −0.167, p = 0.037). Conclusion: After controlling for confounders, serum osteocalcin level was independently associated with LGA in men, which suggested that osteocalcin was closely related with atherosclerosis and vascular dysfunction.