Details

Autor(en) / Beteiligte

• VADALKAR, V. S.
• PREMNATH, V.
• KULKARNI, M. G.
• MASHELKAR, R. A.

Titel

DIFFUSION LIMITATIONS IN ENZYME MIMICING POLYMER MEDIATED REACTIONS

Ist Teil von

• Chemical engineering communications, 1996-10, Vol.152-153 (1), p.139-160

Ort / Verlag

Elmont, NY: Taylor & Francis Group

Erscheinungsjahr

1996

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Diffusional effects in reactions involving macromolecular substrates and reactants in heterogeneous media lead to unique features. We report investigations on the hydrolysis of 2-hydroxy ethyl methacrylate copolymers catalyzed by imidazole and poly (W-vinyl imidazole) selected as an enzyme mimicing polymer. This process has been mathematically modelled, and the predictions compared with experimental findings. The model framework is general for diffusion-reaction problems of this class. The work has also pragmatic relevance in the design of drug delivery systems, since the reaction takes place in pH ranges of physiological significance.