Details

Autor(en) / Beteiligte

• Gagliardi, M. Cristina
• Sallusto, Federica
• Marinaro, Mariarosaria
• Vendetti, Silvia
• Riccomi, Antonella
• De Magistris, M. Teresa

Titel

Effects of the adjuvant cholera toxin on dendritic cells: stimulatory and inhibitory signals that result in the amplification of immune responses

Ist Teil von

• International journal of medical microbiology, 2001, Vol.291 (6), p.571-575

Ort / Verlag

Elsevier GmbH

Erscheinungsjahr

2001

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Cholera toxin (CT) is a potent mucosal adjuvant. When administered through the mucosal route CT amplifies B and T lymphocyte responses to co-administered antigens. Since the discovery of CT as a mucosal adjuvant, other bacterial enterotoxins have been found to have this property. These molecules or their detoxified derivatives are all important for the development of mucosal vaccines for human use, and it is thus necessary to understand their mechanism of action. CT has immunomodulatory effects on different cell types, however, the interaction of CT with dendritic cells (DCs), which have a primary role in the priming of immune responses, may be crucial for its adjuvant activity.