Details

Autor(en) / Beteiligte

• Csordás, György
• Santra, Manoranjan
• Reed, Charles C.
• Eichstetter, Inge
• McQuillan, David J.
• Gross, Danielle
• Nugent, Matthew A.
• Hajnóczky, György
• Iozzo, Renato V.

Titel

Sustained Down-regulation of the Epidermal Growth Factor Receptor by Decorin

Ist Teil von

• The Journal of biological chemistry, 2000-10, Vol.275 (42), p.32879-32887

Ort / Verlag

Elsevier Inc

Erscheinungsjahr

2000

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The small leucine-rich proteoglycan decorin interacts with the epidermal growth factor receptor (EGFR) and triggers a signaling cascade that leads to elevation of endogenous p21 and growth suppression. We demonstrate that decorin causes a sustained down-regulation of the EGFR. Upon stable expression of decorin, the EGFR number is reduced by ∼40%, without changes in EGFR expression. However, EGFR phosphorylation is nearly completely abolished. Concurrently, decorin attenuates the EGFR-mediated mobilization of intracellular calcium and blocks the growth of tumor xenografts by down-regulating the EGFR kinase in vivo. Thus, decorin acts as an autocrine and paracrine regulator of tumor growth and could be utilized as an effective anti-cancer agent.