Details

Autor(en) / Beteiligte

• Makela, M. J.
• Kanehiro, A.
• Borish, L.
• Dakhama, A.
• Loader, J.
• Joetham, A.
• Xing, Z.
• Jordana, M.
• Larsen, G. L.
• Gelfand, E. W.

Titel

IL-10 Is Necessary for the Expression of Airway Hyperresponsiveness but Not Pulmonary Inflammation after Allergic Sensitization

Ist Teil von

• Proceedings of the National Academy of Sciences - PNAS, 2000-05, Vol.97 (11), p.6007-6012

Ort / Verlag

United States: National Academy of Sciences of the United States of America

Erscheinungsjahr

2000

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Cytokines play an important role in modulating inflammatory responses and, as a result, airway tone. IL-10 is a regulatory cytokine that has been suggested for treatment of asthma because of its immunosuppressive and anti-inflammatory properties. In contrast to these suggestions, we demonstrate in a model of allergic sensitization that mice deficient in IL-10 (IL-10-/-) develop a pulmonary inflammatory response but fail to exhibit airway hyperresponsiveness in both in vitro and in vivo assessments of lung function. Reconstitution of these deficient mice with the IL-10 gene fully restores development of airway hyperresponsiveness comparable to control mice. These results identify an important role of IL-10, downstream of the inflammatory cascade, in regulating the tone of the airways after allergic sensitization and challenge.