Details

Autor(en) / Beteiligte

• Lei, Z. Q.
• Li, L.
• Li, G. J.
• Leung, C. W.
• Shi, J.
• Wong, C. M.
• Lo, K. C.
• Chan, W. K.
• Mak, C. S. K.
• Chan, S. B.
• Chan, N. M. M.
• Leung, C. H.
• Lai, P. T.
• Pong, P. W. T.

Titel

Liver cancer immunoassay with magnetic nanoparticles and MgO-based magnetic tunnel junction sensors

Ist Teil von

• Journal of applied physics, 2012-04, Vol.111 (7), p.07E505-07E505-3

Ort / Verlag

American Institute of Physics

Erscheinungsjahr

2012

Quelle

美国小型学会期刊集（AIP Scitation平台）

Beschreibungen/Notizen

• We have demonstrated the detection of alpha-fetoprotein (AFP) labeled with magnetic nanoparticles (MNPs) using MgO-based magnetic tunnel junction (MTJ) sensors. AFP is an important hepatic tumor biomarker and the detection of AFP has significant applications for clinical diagnostics and immunoassay for early-stage liver cancer indications. In this work, MgO-based MTJ sensors and 20-nm iron-oxide magnetic nanoparticles (MNPs) were used for detecting AFP antigens by a sandwich-assay configuration. The MTJ sensors with a sensing area of 4×2 μ m 2 possess tunneling magnetoresistance (TMR) of 122% and sensitivity of 0.95%/Oe at room temperature. The target AFP antigens of three concentrations were successfully detected, and the experimental data indicate that the resistance variations of the MTJ sensor increased with the AFP concentration ratios proportionally. These results demonstrate that MgO-based MTJ sensors together with MNPs are a promising biosensing platform for liver cancer immunoassay.