Details

Autor(en) / Beteiligte

• Smith, John W
• Longo, Dan L
• Alvord, W. Gregory
• Janik, John E
• Sharfman, William H
• Gause, Barry L
• Curti, Brendan D
• Creekmore, Stephen P
• Holmlund, Jon T
• Fenton, Robert G
• Sznol, Mario
• Miller, Langdon L
• Shimizu, Masanao
• Oppenheim, Joost J
• Fiem, Shelby J
• Hursey, Jean C
• Powers, Gerry C
• Urba, Walter J

Titel

The Effects of Treatment with Interleukin-1α on Platelet Recovery after High-Dose Carboplatin

Ist Teil von

• The New England journal of medicine, 1993-03, Vol.328 (11), p.756-761

Ort / Verlag

Boston, MA: Massachusetts Medical Society

Erscheinungsjahr

1993

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• Escalation of the dose of many antineoplastic drugs is limited by granulocytopenia and thrombocytopenia. Although colony-stimulating factors 1 , 2 and the transplantation of bone marrow or peripheral-blood progenitor cells 3 – 6 have had an effect on this problem, there are currently no strategies that permit repeated cycles of high-dose chemotherapy. Thrombocytopenia is not affected by granulocyte colony-stimulating factor 1 or granulocyte-macrophage colony-stimulating factor 2 and rapidly becomes dose-limiting after only moderate increments in chemotherapy despite the use of these factors. However, phase I studies of interleukin-1b 7 , 8 and interleukin-1a 9 have demonstrated that they cause platelet counts to become elevated one to two weeks after . . .