Details

Autor(en) / Beteiligte

• Hauser, A C
• Derfler, K
• Stockenhuber, F
• Wamser, P
• Marosi, L
• Balcke, P

Titel

Effect of Calcium-Channel Blockers on Renal Function in Renal-Graft Recipients Treated with Cyclosporine

Ist Teil von

• The New England journal of medicine, 1991-05, Vol.324 (21), p.1517-1517

Ort / Verlag

United States: Massachusetts Medical Society

Erscheinungsjahr

1991

Quelle

MEDLINE

Beschreibungen/Notizen

• To the Editor: Nephrotoxicity is a serious side effect of cyclosporine therapy 1 that appears to be caused by arteriolar vasoconstriction due to local release of thromboxane A 2 . 2 , 3 Calcium-channel blockers have the capacity to interfere with renal vasoconstriction caused by cyclosporine, 4 and by this mechanism might mitigate cyclosporine nephrotoxicity. This possibility prompted us to compare retrospectively the changes in renal function in 92 patients who received cadaver renal transplants either with or without concomitant calcium-channel—blocker therapy for four years beginning three months after surgery. Twenty-eight patients received a calcium-channel blocker (10 to 40 mg of nifedipine per day in . . .