Details
- Autor(en) / Beteiligte
- Titel
- Anti-angiogenic activity of a homoisoflavanone from Cremastra appendiculata
- Ist Teil von
- Planta medica, 2004-02, Vol.70 (2), p.171-173
- Ort / Verlag
- Stuttgart: Thieme
- Erscheinungsjahr
- 2004
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Abstract A homoisoflavanone, 5,7-dihydroxy-3-(3-hydroxy-4-methoxybenzyl)-6-methoxychroman-4-one (1), was isolated from the bulb of CREMASTRA APPENDICULATA (D. Don) Makino (Orchidaceae) as a potent inhibitor of angiogenesis. It inhibited basic fibroblast growth factor (bFGF)-induced IN VITRO angiogenesis and IN VIVO angiogenesis of the chorioallantoic membrane (CAM) of chick embryo without showing any toxicity.
- Sprache
- Englisch; Deutsch
- Identifikatoren
- ISSN: 0032-0943eISSN: 1439-0221DOI: 10.1055/s-2004-815496Titel-ID: cdi_crossref_primary_10_1055_s_2004_815496
- Format
- –
- Schlagworte
- Angiogenesis Inhibitors - administration & dosage, Angiogenesis Inhibitors - pharmacology, Angiogenesis Inhibitors - therapeutic use, Animals, antiangiogenic activity, Biological and medical sciences, cell proliferation, chemical structure, Chick Embryo, chorioallantoic membrane, Chorion - blood supply, Chorion - drug effects, Cremastra appendiculata, endothelial cells, Fibroblast Growth Factor 2 - drug effects, General pharmacology, homoisoflavanone, humans, isoflavones, Isoflavones - administration & dosage, Isoflavones - pharmacology, Isoflavones - therapeutic use, Letter, Medical sciences, medicinal plants, medicinal properties, Neovascularization, Physiologic - drug effects, Orchidaceae, Pharmacognosy. Homeopathy. Health food, Pharmacology. Drug treatments, physiologic angiogenesis, phytochemicals, Phytotherapy, plant extracts, Plant Extracts - administration & dosage, Plant Extracts - pharmacology, Plant Extracts - therapeutic use, spectral analysis, umbilical veins