Planta medica, 2013-07, Vol.79 (11), p.966-970
2013
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- Autor(en) / Beteiligte
- Titel
- Inhibitory activity of plant stilbenoids against nitric oxide production by lipopolysaccharide-activated microglia
- Ist Teil von
- Planta medica, 2013-07, Vol.79 (11), p.966-970
- Ort / Verlag
- Germany
- Erscheinungsjahr
- 2013
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Microglia-driven inflammatory processes are thought to play an important role in ageing and several neurological disorders. Since consumption of a diet rich in polyphenols has been associated with anti-inflammatory and neuroprotective effects, we studied the effects of twenty-five stilbenoids isolated from Milicia excelsa, Morus alba, Gnetum africanum, and Vitis vinifera. These compounds were tested at 5 and 10 µM on BV-2 microglial cells stimulated with bacterial lipopolysaccharide. Ten stilbenoids reduced lipopolysaccharide-induced nitric oxide production at 5 and/or 10 µM. Two tetramers, E-vitisin A and E-vitisin B, were the most effective molecules. Moreover, they attenuated the expression of the inducible NO synthase protein and gene.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0032-0943eISSN: 1439-0221DOI: 10.1055/s-0032-1328651Titel-ID: cdi_crossref_primary_10_1055_s_0032_1328651
- Format
- –
- Schlagworte
- Animals, Anti-Inflammatory Agents - chemistry, Anti-Inflammatory Agents - pharmacology, Benzofurans - chemistry, Benzofurans - isolation & purification, Benzofurans - pharmacology, Cell Line, Cell Survival - drug effects, Gnetum - chemistry, Lipopolysaccharides - pharmacology, Microglia - drug effects, Microglia - metabolism, Moraceae - chemistry, Morus - chemistry, Neuroprotective Agents - chemistry, Neuroprotective Agents - pharmacology, Nitric Oxide - metabolism, Nitric Oxide Synthase Type II - drug effects, Nitric Oxide Synthase Type II - genetics, Nitric Oxide Synthase Type II - metabolism, Phenols - chemistry, Phenols - isolation & purification, Phenols - pharmacology, Plant Extracts - chemistry, Plant Extracts - isolation & purification, Plant Extracts - pharmacology, Plant Roots - chemistry, Plant Stems - chemistry, Polyphenols - pharmacology, Stilbenes - chemistry, Stilbenes - isolation & purification, Stilbenes - pharmacology, Vitis - chemistry