Details

Autor(en) / Beteiligte

• Liu, Hao-Yang
• Li, Xiao
• Wang, Zhi-Gang
• Liu, Shu-Lin

Titel

Virus-mimicking nanosystems: from design to biomedical applications

Ist Teil von

• Chemical Society reviews, 2023-12, Vol.52 (24), p.8481-8499

Ort / Verlag

England: Royal Society of Chemistry

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• Nanomedicine, as an interdisciplinary discipline involving the development and application of nanoscale materials and technologies, is rapidly developing under the impetus of bionanotechnology and has attracted a great deal of attention from researchers. Especially, with the global outbreak of COVID-19, the in-depth investigation of the infection mechanism of the viruses has made the study of virus-mimicking nanosystems (VMNs) a popular research topic. In this review, we initiate with a brief historical perspective on the emergence and development of VMNs for providing a comprehensive view of the field. Next, we present emerging design principles and functionalization strategies for fabricating VMNs in light of viral infection mechanisms. Then, we describe recent advances in VMNs in biology, with a major emphasis on representative examples. Finally, we summarize the opportunities and challenges that exist in this field, hoping to provide new insights and inspiration to develop VMNs for disease diagnosis and treatment and to attract the interest of more researchers from different fields. This review highlights the design principles and strategies of virus-mimicking nanosystems as well as their current status and challenges in biomedical applications.