Details

Autor(en) / Beteiligte

• Nakajo, Toshinobu
• Kusaka, Shinpei
• Hiraoka, Haruka
• Nomura, Kohei
• Matsubara, Noriaki
• Baba, Rintaro
• Yoshida, Yuki
• Nakamoto, Kosuke
• Honma, Masakazu
• Iguchi, Hiroaki
• Uchihashi, Takayuki
• Abe, Hiroshi
• Matsuda, Ryotaro

Titel

Creation of single molecular conjugates of metal-organic cages and DNA

Ist Teil von

• Chemical communications (Cambridge, England), 2023-04, Vol.59 (33), p.4974-4977

Ort / Verlag

England: Royal Society of Chemistry

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• Here we report the development of an equimolar conjugate of a metal - organic cage (MOC) and DNA ( MOC-DNA ). Several MOC-DNA conjugates were assembled into a programmed structure by coordinating with a template DNA having a complementary base sequence. Moreover, conjugation with the MOC drastically enhanced the permeability of DNA through the lipid bilayer, presenting great potential as a drug delivery system. We report the development of an equimolar conjugate of a metal - organic cage (MOC) and DNA ( MOC-DNA ) for the first time. The unique functions derived from the conjugation are also reported.