Details

Autor(en) / Beteiligte

• Tang, Na
• Zhu, Yi
• Lu, Ziwei
• Deng, Jiali
• Guo, Jiajing
• Ding, Xinyi
• Wang, Jingyi
• Cao, Rong
• Chen, An
• Huang, Zhongyi
• Lu, Hongwei
• Wang, Zhongling

Titel

pH-Responsive doxorubicin-loaded magnetosomes for magnetic resonance-guided focused ultrasound real-time monitoring and ablation of breast cancer

Ist Teil von

• Biomaterials science, 2023-10, Vol.11 (21), p.7158-7168

Ort / Verlag

Cambridge: Royal Society of Chemistry

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• MR-guided focused ultrasound surgery (MRgFUS) is driving a new direction in non-invasive thermal ablation therapy with spatial specificity and real-time temperature monitoring. Although widely used in clinical practice, it remains challenging to completely ablate the tumor margin due to fear of damaging the surrounding tissues, thus leading to low efficacy and a series of complications. Herein, we have developed novel pH-responsive drug-loading magnetosomes (STPSD nanoplatform) for increasing the T 2 -contrast and improved the ablation efficiency with a clinical MRgFUS system. Specifically, this STPSD nanoplatform is functionalized by pH-responsive peptides (STP-TPE), encapsulating superparamagnetic iron oxide (SPIO) and doxorubicin (DOX), which can cause drug release and SPIO deposition at the tumor site triggered by acidity and MRgFUS. Under MRgFUS treatment, the increased vascular permeability caused by hyperthermia can improve the uptake of SPIO and DOX by tumor cells, so as to enhance ultrasound energy absorption and further enhance the efficacy of chemotherapy to completely ablate tumor margins. Moreover, we demonstrated that a series of MR sequences including T 2 -weighted imaging ( T 2 WI), contrast-enhanced T 1 WI imaging ( T 1 WI C+), maximum intensity projection (MIP), volume rendering (VR) and ADC mapping can be further utilized to monitor the MRgFUS ablation effect in rat models. Overall, this smart nanoplatform has the capacity to be a powerful tool to promote the therapeutic MRgFUS effect and minimize the side effects to surrounding tissues. We have successfully prepared pH-responsive doxorubicin-loaded magnetosomes as an integrated diagnostic and theranostic nanoplatform that is responsive to an acidic microenvironment and can be a synergistic sensitizer for MRgFUS ablation therapy.