Details

Autor(en) / Beteiligte

• Chen, Quan-Bing
• Shen, Mei-Hua
• Ren, Xiao-He
• Zhu, Shuai
• Shang, Jin-Ting
• Liu, Wei
• Zhang, Zhao-Wei
• Dong, Zhi-Jun
• Gu, Hua-Zhi
• Zhang, Xian-Zheng
• Yuan, Qiong
• Zou, Tao

Titel

Tumor-triggered targeting ammonium bicarbonate liposomes for tumor multimodal therapy

Ist Teil von

• Journal of materials chemistry. B, Materials for biology and medicine, 2022-07, Vol.1 (27), p.5154-5164

Ort / Verlag

England: Royal Society of Chemistry

Erscheinungsjahr

2022

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Tumor-triggered targeting ammonium bicarbonate (TTABC) liposomes were proposed to improve the uptake of ammonium bicarbonate (ABC) liposomes in tumor cells and retain their long circulation in vivo in our previous study. However, it must be solved how to precisely release the loaded drugs of the TTABC liposomes into tumor cells. In addition, synergistic multimodal therapy could result in better tumor treatment outcomes than monomodal chemotherapy. In the research, we prepared indocyanine green (ICG) and doxorubicin (DOX) encapsulated TTABC liposomes (ICG&DOX@TTABC) to achieve near-infrared (NIR) light-controlled chemo/photothermal/photodynamic multimodal therapy guided by fluorescence and photothermal imaging. In vitro and vivo studies show that ICG&DOX@TTABC can specifically accumulate in tumor tissues, effectively transform NIR light into local thermo-therapy, and have excellent anti-tumor ability without obvious side effects. ICG&DOX@TTABC could be promising for fluorescence and photothermal imaging-guided chemo/photothermal/photodynamic tumor treatment. Indocyanine green (ICG) and doxorubicin (DOX) encapsulated TTABC liposomes (ICG&DOX@TTABC) were prepared to achieve near-infrared light-controlled chemo/photothermal/photodynamic multimodal therapy guided by fluorescence and photothermal imaging.