Details

Autor(en) / Beteiligte

• Meenakshi, Maniarasu
• Srinivasan, Kannupal

Titel

SnCl 4 -mediated one-pot synthesis of 2,4,5-trisubstituted thiazoles from nitro-substituted donor-acceptor cyclopropanes and thioamides

Ist Teil von

• Organic & biomolecular chemistry, 2022-11, Vol.20 (44), p.8741-8746

Ort / Verlag

England

Erscheinungsjahr

2022

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The treatment of nitro-substituted donor-acceptor cyclopropanes (DACs) with SnCl and the subsequent reaction with thioamides provide one-pot access to various thiazole derivatives. Aroylmethylidene malonates were produced as intermediates in the reactions and they underwent conjugate addition followed by cyclocondensation with thioamides to afford the products. This work demonstrates the versatility of this class of cyclopropanes in synthesizing all three 1,3-azoles.