Details

Autor(en) / Beteiligte

• Wang, Xiaoyu
• Ma, Qing
• Wen, Chaochao
• Gong, Tao
• Li, Jing
• Liang, Wenting
• Li, Meining
• Wang, Yuyao
• Guo, Rui

Titel

Folic acid and deoxycholic acid derivative modified Fe 3 O 4 nanoparticles for efficient pH-dependent drug release and multi-targeting against liver cancer cells

Ist Teil von

• RSC advances, 2021-12, Vol.11 (63), p.39804-39812

Ort / Verlag

England

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• The novel nano-drug carrier (FDCA-FA-MNPs) was constructed by grafting formyl deoxycholic acid (FDCA) and folic acid (FA) on the surface of Fe O magnetic nanoparticles (MNPs), possessing the advantages of superparamagnetism, good stability, low cytotoxicity and good blood compatibility. The hydrophobic anti-cancer drug doxorubicin hydrochloride (DOX) was successfully loaded onto FDCA-FA-MNPs through supramolecular interactions (hydrogen bond between FDCA and drug and hydrophobic interaction and π-π stacking between drug and drug). The drug loading amount and drug loading capacity were 509.1 mg g and 33.73 wt%, respectively. In addition, drug release had a pH responsive and controllable release performance, the release rate at pH 5.3 (45.6%) was four times that at pH 7.4 (11.5%), and the tumor microenvironment was favorable for drug release. More importantly, the novel nano-drug carrier combined the hepatocellular targeting of FDCA, the cancer cell targeting of FA, and the magnetic targeting of Fe O , showing excellent cancer-killing efficiency (78%) . Therefore, the nano-drug carrier synthesized in this paper has potential practical application value in the targeted therapy of liver cancer.