Details

Autor(en) / Beteiligte

• Pandey, Shalini
• Sharma, Virender Kumar
• Biswas, Ankur
• Lahiri, Mayurika
• Basu, Sudipta

Titel

Small molecule-mediated induction of endoplasmic reticulum stress in cancer cells

Ist Teil von

• RSC medicinal chemistry, 2021-09, Vol.12 (9), p.164-1611

Ort / Verlag

RSC

Erscheinungsjahr

2021

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The endoplasmic reticulum (ER) is one of the crucial sub-cellular organelles controlling myriads of functions including protein biosynthesis, folding, misfolding and unfolding. As a result, dysregulation of these pathways in the ER is implicated in cancer development and progression. Subsequently, targeting the ER in cancer cells emerged as an interesting unorthodox strategy in next-generation anticancer therapy. However, development of small molecules to selectively target the ER for cancer therapy remained elusive and unexplored. To address this, herein, we have developed a novel small molecule library of sulfonylhydrazide-hydrazones through a short and concise chemical synthetic strategy. We identified a fluorescent small molecule that localized into the endoplasmic reticulum (ER) of HeLa cells, induced ER stress followed by triggering autophagy which was subsequently inhibited by chloroquine (autophagy inhibitor) to initiate apoptosis. This small molecule showed remarkable cancer cell killing efficacy in different cancer cells as mono and combination therapy with chloroquine, thus opening a new direction to illuminate ER-biology towards the development of novel anticancer therapeutics. Sulfononylhydrazide-hydrazone based small molecules as ER stress modulators for anti-cancer therapy