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A novel pH-responsive Fe-MOF system for enhanced cancer treatment mediated by the Fenton reaction
Ist Teil von
New journal of chemistry, 2021-02, Vol.45 (6), p.3271-3279
Ort / Verlag
Cambridge: Royal Society of Chemistry
Erscheinungsjahr
2021
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
Recently, the toxic hydroxyl radical (·OH) has received wide interest for inducing cell apoptosis by increasing the intracellular reactive oxygen species (ROS) levels. Herein, a cationic polymer (MV-PAH) was rationally synthesized, and a new pH-responsive nanoreactor (DOX@Fe-MOF@PEM) was modified with the prepared cationic polymer MV-PAH multilayers by layer-by-layer (LBL) technique. The polyelectrolyte multilayer (PEM) disassembled and notably enhanced drug delivery in the weak acid environment of the tumor cell. In the cytotoxicity and apoptosis experiments, DOX@Fe-MOF@PEM revealed an advanced repression of cancer. The H
2
O
2
induced by DOX and MV-PAH could be catalyzed to generate hypertoxic ·OH through intracellular iron ions based on a Fenton-like reaction, which thereby improved the anticancer effect of DOX. This realistic strategy may create a potential way to provide a combination of ROS and chemotherapy to improve the anti-cancer effect.
A novel pH-responsive Fe-MOF system for enhancing cancer treatment mediated by a Fenton reaction.