Details

Autor(en) / Beteiligte

• Ha, Phuong Thu
• Le, Thi Thu Huong
• Ung, Thi Dieu Thuy
• Do, Hai Doan
• Doan, Bich Thuy
• Mai, Thi Thu Trang
• Pham, Hong Nam
• Hoang, Thi My Nhung
• Phan, Ke Son
• Bui, Thuc Quang

Titel

Properties and bioeffects of magneto-near infrared nanoparticles on cancer diagnosis and treatment

Ist Teil von

• New journal of chemistry, 2020-10, Vol.44 (4), p.17277-17288

Ort / Verlag

Cambridge: Royal Society of Chemistry

Erscheinungsjahr

2020

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• In this study, a multifunctional drug delivery nanosystem Fe 3 O 4 -CdTe-alginate (FAQ) was prepared by coating Fe 3 O 4 nanoparticles and CdTe quantum dots (QDs) simultaneously with alginate. High luminescent CdTe QDs can help label the cells for diagnostics while the superparamagnetic Fe 3 O 4 component endows the abilities of hyperthermia and magnetic targeting to the system for cancer treatment. Besides, polymeric alginate provides biocompatibility and high stability (Zeta potential of −49.1 mV) and makes it possible to encapsulate cancer drug Doxorubicin (Dox) in the system. The fluorescence spectra of blank FAQ and FAQ loading Dox (FAQD) were analysed and compared to those of pure CdTe or Dox to confirm the formation of the nanosystems. Next, the samples were applied to in vitro treatment with several human cell lines (Hep-G2, LU-1, RD and Vero cell lines) and showed positive results with low IC 50 values for these cells and exhibited higher impact of apoptosis induction and MCF7 spheroid growth delay compared to pure Dox. In particular, FAQ and FAQD have high values of r 2 and show contrast increment in the MRI images. The results indicate that FAQ and FAQD can serve as excellent candidates for both cancer therapy and diagnostics. The developed nanosystem could be an effective cancer drug deliverer, MRI contrast enhancer and near infrared fluorescent probe.