Details

Autor(en) / Beteiligte

• Zhang, Shaoke
• Weniger, Florian
• Ye, Fei
• Rabeah, Jabor
• Ellinger, Stefan
• Zaragoza, Florencio
• Taeschler, Christoph
• Neumann, Helfried
• Brückner, Angelika
• Beller, Matthias

Titel

Selective nickel-catalyzed fluoroalkylations of olefins

Ist Teil von

• Chemical communications (Cambridge, England), 2020-12, Vol.56 (96), p.15157-1516

Ort / Verlag

England: Royal Society of Chemistry

Erscheinungsjahr

2020

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Mild and selective nickel-catalyzed trifluoromethylation and perfluoroalkylation reactions of alkenes were developed to provide fluorinated olefins, including natural products, pharmaceuticals, and variety of synthetic building blocks in good to excellent yields (38 examples). Control experiments, kinetic measurements and in situ EPR studies reveal the importance of radical species and the formation of 1,2-adducts as intermediates. Fluoroalkylated olefins made easy: a mild and selective Ni-catalyzed fluoroalkylation including trifluoromethylation of alkenes was developed. Various fluorinated olefins were provided in good to excellent yields.