Details

Autor(en) / Beteiligte

• Zhang, Jianjian
• Ning, Lulu
• Huang, Jiaguo
• Zhang, Chi
• Pu, Kanyi

Titel

Activatable molecular agents for cancer theranostics

Ist Teil von

• Chemical science (Cambridge), 2020, Vol.11 (3), p.618-63

Ort / Verlag

England: Royal Society of Chemistry

Erscheinungsjahr

2020

Quelle

Open access e-journals list

Beschreibungen/Notizen

• Theranostics that integrates diagnosis and treatment modalities has attracted great attention due to its abilities of personalized therapy and real-time monitoring of therapeutic outcome. Such a theranostic paradigm requires agents to simultaneously possess the capabilities of targeting, imaging, and treatment. Activatable molecular agents (AMAs) are promising for cancer theranostics, as they show a higher signal-to-noise ratio (SNR), real-time detection of cancer-associated biomarkers, lower normal tissue toxicity, and a higher therapeutic effect. This perspective summarizes the recent advancements of AMAs, which include imaging-guided chemotherapy, imaging-guided photodynamic therapy, and imaging-guided photothermal therapy. The molecular design principles, theranostic mechanisms, and biomedical applications of AMAs are described, followed by a discussion of potential challenges of AMAs in cancer theranostics. Activatable molecualr agents that intergrate diagnosis and treatment modalities have attracted great attention due to its abilities of personalized therapy and real-time monitoring of therapeutic outcome.