Details

Autor(en) / Beteiligte

• Shao, Wenting
• Burkert, Seth C
• White, David L
• Scott, Valerie L
• Ding, Jianfu
• Li, Zhao
• Ouyang, Jianying
• Lapointe, François
• Malenfant, Patrick R L
• Islam, Kabirul
• Star, Alexander

Titel

Probing Ca 2+ -induced conformational change of calmodulin with gold nanoparticle-decorated single-walled carbon nanotube field-effect transistors

Ist Teil von

• Nanoscale, 2019-07, Vol.11 (28), p.13397-13406

Ort / Verlag

England

Erscheinungsjahr

2019

Quelle

MEDLINE

Beschreibungen/Notizen

• Nanomaterials are ideal for electrochemical biosensors, with their nanoscale dimensions enabling the sensitive probing of biomolecular interactions. In this study, we compare field-effect transistors (FET) comprised of unsorted (un-) and semiconducting-enriched (sc-) single-walled carbon nanotubes (SWCNTs). un-SWCNTs have both metallic and semiconducting SWCNTs in the ensemble, while sc-SWCNTs have a >99.9% purity of semiconducting nanotubes. Both SWCNT FET devices were decorated with gold nanoparticles (AuNPs) and were then employed in investigating the Ca -induced conformational change of calmodulin (CaM) - a vital process in calcium signal transduction in the human body. Different biosensing behavior was observed from FET characteristics of the two types of SWCNTs, with sc-SWCNT FET devices displaying better sensing performance with a dynamic range from 10 M to 10 M Ca , and a lower limit of detection at 10 M Ca .