Details

Autor(en) / Beteiligte

• Cui, Hai-Bo
• Xie, Ling-Zhi
• Wan, Nan-Wei
• He, Qing
• Li, Zhi
• Chen, Yong-Zheng

Titel

Cascade bio-hydroxylation and dehalogenation for one-pot enantioselective synthesis of optically active β-halohydrins from halohydrocarbons

Ist Teil von

• Green chemistry : an international journal and green chemistry resource : GC, 2019-08, Vol.21 (16), p.4324-4328

Ort / Verlag

Cambridge: Royal Society of Chemistry

Erscheinungsjahr

2019

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A stereoselective hydroxylation and enantioselective dehalogenation cascade reaction was developed for the synthesis of optically active β-haloalcohols from halohydrocarbons. This cascade system employed P450 and halohydrin dehalogenase as two compatible biocatalysts, allowing a straightforward, greener and efficient access to β-halohydrins with excellent enantioselectivities (98-99%). A stereoselective hydroxylation and enantioselective dehalogenation cascade reaction was developed for the synthesis of optically active β-haloalcohols from halohydrocarbons.