Details

Autor(en) / Beteiligte

• Chansaenpak, Kantapat
• Vabre, Boris
• Gabba, Franois. P

Titel

[18F]-Group 13 fluoride derivatives as radiotracers for positron emission tomography

Ist Teil von

• Chemical Society reviews, 2016-01, Vol.45 (4), p.954-971

Ort / Verlag

England

Erscheinungsjahr

2016

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The field of 18 F chemistry is rapidly expanding because of the use of this radionuclide in radiotracers for positron emission tomography (PET). Until recently, most [ 18 F]-radiotracers were generated by the direct attachment of 18 F to a carbon in the organic backbone of the radiotracer. The past decade has witnessed the emergence of a new strategy based on the formation of an 18 F-group 13 element bond. This approach, which is rooted in the field of fluoride anion complexation/coordination chemistry, has led to the development of a remarkable family of boron, aluminium and gallium [ 18 F]-fluoride anion complexing agents which can be conjugated with peptides and small molecules to generate disease specific PET radiotracers. This review is dedicated to the chemistry of these group 13 [ 18 F]-fluorides anion complexing agents and their use in PET. Some of the key fluoride-binding motifs covered in this review include the trifluoroborate unit bound to neutral or cationic electron deficient backbones, the BF 2 unit of BODIPY dyes, and AlF or GaF 3 units coordinated to multidentate Lewis basic ligands. In addition to describing how these moieties can be converted into their [ 18 F]-analogs, this review also dicusses their incorporation into bioconjugates for application in PET. This article reviews the radiofluorination chemistry of group 13 derivative as well as their use for 18F-PET Imaging.