Details

Autor(en) / Beteiligte

• Fosso, Marina Y.
• Li, Yijia
• Garneau-Tsodikova, Sylvie

Titel

New trends in the use of aminoglycosides

Ist Teil von

• MedChemComm, 2014, Vol.5 (8), p.1075-1091

Erscheinungsjahr

2014

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Despite their inherent toxicity and the acquired bacterial resistance that continuously threaten their long-term clinical use, aminoglycosides (AGs) still remain valuable components of the antibiotic armamentarium. Recent literature shows that the AGs' role has been further expanded as multi-tasking players in different areas of study. This review aims at presenting some of the new trends observed in the use of AGs in the past decade, along with the current understanding of their mechanisms of action in various bacterial and eukaryotic cellular processes.