Details

Autor(en) / Beteiligte

• Via, Dolores
• Matos, Maria Joo
• Yez, Matilde
• Santana, Lourdes
• Uriarte, Eugenio

Titel

3-Substituted coumarins as dual inhibitors of AChE and MAO for the treatment of Alzheimer's disease

Ist Teil von

• MedChemComm, 2012-02, Vol.3 (2), p.213-218

Erscheinungsjahr

2012

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The complex etiology of Alzheimer's disease (AD) has encouraged active research in the development of multi-target drugs with two or more complementary biological activities, since they may represent an important advance in the treatment of this disease. A series of 3-substituted coumarins were synthesized and evaluated as monoamino oxidases (MAO) and acetylcholinesterase (AChE) inhibitors. Most of the 3-benzamide coumarin derivatives inhibited both MAO-B and AChE with values in the micromolar range. It might be a promising direction for developing novel drugs as potential agents for the treatment of AD patients. Three series of 3-substituted coumarin derivatives have been synthesized and evaluated as dual hMAO/hAChE inhibitors. The importance of the substituents in that position is determined.