Details

Autor(en) / Beteiligte

• Chou, Leo Y. T
• Ming, Kevin
• Chan, Warren C. W

Titel

Strategies for the intracellular delivery of nanoparticles

Ist Teil von

• Chemical Society reviews, 2011-01, Vol.4 (1), p.233-245

Ort / Verlag

England

Erscheinungsjahr

2011

Quelle

MEDLINE

Beschreibungen/Notizen

• The ability to target contrast agents and therapeutics inside cells is becoming important as we strive to decipher the complex network of events that occur within living cells and design therapies that can modulate these processes. Nanotechnology researchers have generated a growing list of nanoparticles designed for such applications. These particles can be assembled from a variety of materials into desirable geometries and configurations and possess useful properties and functionalities. Undoubtedly, the effective delivery of these nanomaterials into cells will be critical to their applications. In this tutorial review , we discuss the fundamental challenges of delivering nanoparticles into cells and to the targeted organelles, and summarize strategies that have been developed to-date. Development of intracellular delivery strategies for nanoparticles is important to their applications in imaging, bio-sensing, and therapeutics. Here we highlight the current state-of-the-art in delivery strategies and challenges.