Details

Autor(en) / Beteiligte

• Bishop on behalf of the GenoMEL Consortium, D Timothy
• Barrett, Jennifer H
• Iles, Mark M
• Harland, Mark
• Taylor, John C
• Aitken, Joanne F
• Andresen, Per Arne
• Akslen, Lars A
• Armstrong, Bruce K
• Avril, Marie-Francoise
• Azizi, Esther
• Bakker, Bert
• Bergman, Wilma
• Bianchi-Scarrà, Giovanna
• Bressac-de Paillerets, Brigitte
• Calista, Donato
• Cannon-Albright, Lisa A
• Corda, Eve
• Cust, Anne E
• D bniak, Tadeusz
• Duffy, David
• Dunning, Alison M
• Easton, Douglas F
• Friedman, Eitan
• Galan, Pilar
• Ghiorzo, Paola
• Giles, Graham G
• Hansson, Johan
• Hocevar, Marko
• Höiom, Veronica
• Hopper, John L
• Ingvar, Christian
• Janssen, Bart
• Jenkins, Mark A
• Jönsson, Göran
• Kefford, Richard F
• Landi, Giorgio
• Landi, Maria Teresa
• Lang, Julie
• Lubi ski, Jan
• Mackie, Rona
• Malvehy, Josep
• Martin, Nicholas G
• Molven, Anders
• Montgomery, Grant W
• van Nieuwpoort, Frans A
• Novakovic, Srdjan
• Olsson, Håkan
• Pastorino, Lorenza
• Puig, Susana
• Puig-Butille, Joan Anton
• Randerson-Moor, Juliette
• Snowden, Helen
• Tuominen, Rainer
• Van Belle, Patricia
• van der Stoep, Nienke
• Whiteman, David C
• Zelenika, Diana
• Han, Jiali
• Fang, Shenying
• Lee, Jeffrey E
• Wei, Qingyi
• Lathrop, G Mark
• Gillanders, Elizabeth M
• Brown, Kevin M
• Goldstein, Alisa M
• Kanetsky, Peter A
• Mann, Graham J
• MacGregor, Stuart
• Elder, David E
• Amos, Christopher I
• Hayward, Nicholas K
• Gruis, Nelleke A
• Demenais, Florence
• Bishop, Julia A Newton

Titel

Genome-wide association study identifies three new melanoma susceptibility loci

Ist Teil von

• Nature genetics, 2011-11, Vol.43 (11), p.1108-1113

Ort / Verlag

New York: Nature Publishing Group US

Erscheinungsjahr

2011

Quelle

MEDLINE

Beschreibungen/Notizen

• We report a genome-wide association study for melanoma that was conducted by the GenoMEL Consortium. Our discovery phase included 2,981 individuals with melanoma and 1,982 study-specific control individuals of European ancestry, as well as an additional 6,426 control subjects from French or British populations, all of whom were genotyped for 317,000 or 610,000 single-nucleotide polymorphisms (SNPs). Our analysis replicated previously known melanoma susceptibility loci. Seven new regions with at least one SNP with P < 10−5 and further local imputed or genotyped support were selected for replication using two other genome-wide studies (from Australia and Texas, USA). Additional replication came from case-control series from the UK and The Netherlands. Variants at three of the seven loci replicated at P < 10−3: an SNP in ATM (rs1801516, overall P = 3.4 × 10−9), an SNP in MX2 (rs45430, P = 2.9 × 10−9) and an SNP adjacent to CASP8 (rs13016963, P = 8.6 × 10−10). A fourth locus near CCND1 remains of potential interest, showing suggestive but inconclusive evidence of replication (rs1485993, overall P = 4.6 × 10−7 under a fixed-effects model and P = 1.2 × 10−3 under a random-effects model). These newly associated variants showed no association with nevus or pigmentation phenotypes in a large British case-control series.