Clinical pharmacology and therapeutics, 2009-08, Vol.86 (2), p.139-146
2009
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Details
- Autor(en) / Beteiligte
- Titel
- New Antithrombotic Drugs
- Ist Teil von
- Clinical pharmacology and therapeutics, 2009-08, Vol.86 (2), p.139-146
- Ort / Verlag
- Basingstoke: Nature Publishing Group
- Erscheinungsjahr
- 2009
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Thrombosis, both venous and arterial, is a major cause of morbidity and mortality worldwide. Consequently, there is an ongoing search for new antithrombotic drugs, particularly novel antiplatelet agents and anticoagulants. A better understanding of the biochemical pathways involved in platelet activation and coagulation and of the links between these systems and the impact of thrombosis on inflammation has led to the identification of new targets for antithrombotic drugs. This paper focuses on these new targets and new antiplatelet drugs and anticoagulants and describes the major advances in the continuing search for more potent antithrombotic drugs that have limited effects on hemostasis. Clinical Pharmacology & Therapeutics (2009); 86, 2, 139–146 doi:10.1038/clpt.2009.98
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0009-9236eISSN: 1532-6535DOI: 10.1038/clpt.2009.98Titel-ID: cdi_crossref_primary_10_1038_clpt_2009_98
- Format
- –
- Schlagworte
- Animals, Anticoagulants - adverse effects, Anticoagulants - pharmacology, Antithrombin III - pharmacology, Biological and medical sciences, Drug Design, Fibrinolytic Agents - adverse effects, Fibrinolytic Agents - pharmacology, Health Services Needs and Demand, Humans, Inflammation - drug therapy, Inflammation - metabolism, Medical sciences, Pharmacology. Drug treatments, Phosphodiesterase Inhibitors - pharmacology, Platelet Aggregation Inhibitors - adverse effects, Platelet Aggregation Inhibitors - pharmacology, Purinergic P2 Receptor Antagonists, Receptor, PAR-1 - antagonists & inhibitors, Receptors, Purinergic P2Y12, Thrombin - antagonists & inhibitors, Thromboxane A2 - antagonists & inhibitors, Vitamin K - antagonists & inhibitors