Clinical pharmacology and therapeutics, 2008-12, Vol.84 (6), p.729-733
2008
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Details
- Autor(en) / Beteiligte
- Titel
- Discrete Event Simulation Applied to Pediatric Phase I Oncology Designs
- Ist Teil von
- Clinical pharmacology and therapeutics, 2008-12, Vol.84 (6), p.729-733
- Ort / Verlag
- Basingstoke: Nature Publishing Group
- Erscheinungsjahr
- 2008
- Quelle
- Wiley-Blackwell Journals
- Beschreibungen/Notizen
- Little attention has been paid to the study of trial efficiency despite increasing pressures to conduct clinical research in an expedient manner and the ever‐present “time is money” mantra that governs the pharmaceutical research concerned with drug development. Still less appreciated is the impact that trial inefficiency can have when studies compete for a finite study population desperate to test potentially lifesaving new medicines. We have used discrete event simulation techniques to examine such sensitivities in pediatric oncology. Clinical Pharmacology & Therapeutics (2008); 84, 6, 729–733 doi:10.1038/clpt.2008.193
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0009-9236eISSN: 1532-6535DOI: 10.1038/clpt.2008.193Titel-ID: cdi_crossref_primary_10_1038_clpt_2008_193
- Format
- –
- Schlagworte
- Antineoplastic Combined Chemotherapy Protocols - administration & dosage, Antineoplastic Combined Chemotherapy Protocols - adverse effects, Biological and medical sciences, Child, Child, Preschool, Clinical Trials, Phase I as Topic, Computer Simulation, Dose-Response Relationship, Drug, Drug Administration Schedule, Female, Humans, Male, Maximum Tolerated Dose, Medical Oncology - organization & administration, Medical sciences, Models, Statistical, Neoplasms - drug therapy, Neoplasms - pathology, Patient Selection, Pediatrics - organization & administration, Pharmacology. Drug treatments, Research Design, Risk Assessment, Sensitivity and Specificity