Details

Autor(en) / Beteiligte

• Anthes, Robert
• Bello, Osagie
• Benoit, Serge
• Chen, Chien-Kuang
• Corbett, Elisabeth
• Corbett, Richard M
• DelMonte, Albert J
• Gingras, Stephane
• Livingston, Robert
• Sausker, Justin
• Soumeillant, Maxime

Titel

Kilogram Synthesis of a Selective Serotonin Reuptake Inhibitor

Ist Teil von

• Organic process research & development, 2008-03, Vol.12 (2), p.168-177

Ort / Verlag

American Chemical Society

Erscheinungsjahr

2008

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Process development of a selective serotonin reuptake inhibitor (1) is described. The synthesis features Nishiyama catalyst-mediated asymmetric cyclopropanation of vinyl indole 2 with ethyldiazoacetate to install the trans-disubstituted cyclopropane. The active pharmaceutical ingredient (1) was prepared in 13 chemical steps with 9 isolations and proceeded in an overall yield of 34%.