Details

Autor(en) / Beteiligte

• Fukui, Yuki
• Oda, Shinichi
• Suzuki, Hiroyuki
• Hakogi, Toshikazu
• Yamada, Daisuke
• Takagi, Yohei
• Aoyama, Yasunori
• Kitamura, Hideyuki
• Ogawa, Masayoshi
• Kikuchi, Junko

Titel

Process Optimization of Aldol-Type Reaction by Process Understanding Using in Situ IR

Ist Teil von

• Organic process research & development, 2012-11, Vol.16 (11), p.1783-1786

Ort / Verlag

American Chemical Society

Erscheinungsjahr

2012

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A high-yield robust LHMDS-mediated aldol-type reaction of benzyl maltol (2) and benzaldehyde (3) was developed using in situ IR to overcome the problems of low yield and yield fluctuation of the pilot synthesis. In situ IR studies indicated that unexpected side reactions of LHMDS and 3 reduced the yield of the aldol-type reaction. On the basis of the results, the reaction conditions were optimized.