Journal of natural products (Washington, D.C.), 1997-09, Vol.60 (9), p.884-888
1997
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- In Vitro Anti-HIV Activity of Biflavonoids Isolated from Rhus succedanea and Garcinia multiflora
- Ist Teil von
- Journal of natural products (Washington, D.C.), 1997-09, Vol.60 (9), p.884-888
- Ort / Verlag
- Washington, DC: American Chemical Society
- Erscheinungsjahr
- 1997
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Eleven biflavonoids, including amentoflavone (1), agathisflavone (2), robustaflavone (3), hinokiflavone (4), volkensiflavone (5), morelloflavone (7), rhusflavanone (9), succedaneaflavanone (10), GB-1a (11), GB-1a 7‘‘-O-β-glucoside (13), and GB-2a (14) isolated from Rhus succedanea and Garcinia multiflora, as well as their methyl ethers, volkensiflavone hexamethyl ether (6), morelloflavone heptamethyl ether (8), and GB-1a hexamethyl ether (12), were evaluated for their anti-HIV-1 RT activity. The results indicated that compounds 3 and 4 demonstrated similar activity against HIV-1 reverse transcriptase (RT), with IC50 values of 65 μM. Compounds 1, 2, 7, 11, and 14 were moderately active against HIV-1 RT, with IC50 values of 119 μM, 100 μM, 116 μM, 236 μM, and 170 μM, respectively. Morelloflavone (7) also demonstrated significant antiviral activity against HIV-1 (strain LAV-1) in phytohemagglutinin-stimulated primary human peripheral blood mononuclear cells at an EC50 value of 6.9 μM and a selectivity index value of approximately 10. The other biflavonoids were either weakly active, inactive, or not selective against HIV-1 in human lymphocytes.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0163-3864eISSN: 1520-6025DOI: 10.1021/np9700275Titel-ID: cdi_crossref_primary_10_1021_np9700275
- Format
- –
- Schlagworte
- AGATHISFLAVONE, AMENTOFLAVONE, Anti-HIV Agents - isolation & purification, Anti-HIV Agents - pharmacology, ANTIVIRAL, ANTIVIRAL AGENTS, Biological and medical sciences, BRANCHE, BRANCHES, Cell Survival - drug effects, Cells, Cultured, CHEMICAL COMPOSITION, CHEMICAL STRUCTURE, COMPOSICION QUIMICA, COMPOSITION CHIMIQUE, DRUG PLANTS, ESPECTROMETRIA, ESTRUCTURA QUIMICA, FEUILLE, FLAVONOIDE, FLAVONOIDES, FLAVONOIDS, Flavonoids - isolation & purification, Flavonoids - pharmacology, GARCINIA, GB-1A 7"-O-BETA-GLUCOSIDE, GB-1A HEXAMETHYL ETHER, GB-2A, General pharmacology, GENERO HUMANO, GENRE HUMAIN, GN-1A, HERPETOVIRIDAE, HINOKIFLAVONE, HIV Reverse Transcriptase - antagonists & inhibitors, HIV-1 - drug effects, HOJAS, HUMAN IMMUNODEFICIENCY VIRUS, Humans, LEAVES, Lymphocytes - drug effects, Lymphocytes - metabolism, MANKIND, Medical sciences, MORELLOFLAVONE, MORELLOFLAVONE HEPTAMETHYL ETHER, Pharmacognosy. Homeopathy. Health food, Pharmacology. Drug treatments, PLANTAS MEDICINALES, PLANTE MEDICINALE, Plants, Medicinal - chemistry, Plants, Toxic, RAMAS, Reverse Transcriptase Inhibitors - pharmacology, RHUS, RHUSFLAVANONE, ROBUSTAFLAVONE, SPECTRAL ANALYSIS, SPECTROMETRIE, SPECTROMETRY, STRUCTURE CHIMIQUE, SUCCEDANEAFLAVANONE, TAIWAN, Toxicodendron - chemistry, VIRICIDAS, Virus Replication - drug effects, VOLKENSIFLAVONE, VOLKENSIFLAVONE HEXAMETHYL ETHER